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Farbod Bahreini
Biochemistry
Cancer Immunology

Dr. Farbod Bahreini

Postdoctoral researcher specializing in tumor biology and cancer immunology, with a focus on prostate cancer bone metastasis, integrin signaling, and tumor–microenvironment interactions. My background combines immunology and translational oncology, with expertise in T cell receptor repertoire analysis, RNA-seq, flow cytometry, and biochemistry.

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Main Postdoc Focus

Tumor biology and bone metastasis

Cancer and integrin signaling

Tumor immunology and microenvironment

Research Interests

T Cell Receptor Repertoire

Protein Biochemistry

Cancer Biomarker

Translational molecular oncology

Tumor biology and metastasis

Education

01.01.2022-02.04.2026: Ph.D. Candidate, Immunology, University of Luebeck, Luebeck, Germany, Thesis: CD4+ T cell receptor sequences during progression towards experimental pemphigoid Supervisor: Prof. Dr. Kathrin Kalies

2018-2021: M.Sc., Biochemistry, Tarbiat Modares University, Tehran, Iran, Thesis: Investigation of structural, activity, and stability alterations of lactate dehydrogenase in the presence of different additives, Supervisor: Prof. Dr. Khosro Khajeh

2014-2018: B.Sc., Cell and Molecular Biology, Guilan University, Rasht, Iran, Thesis: The relation between miR-559 gene polymorphism and the incidence of breast and gastric cancers, Supervisors: Prof. Dr. Zivar Salehi, Dr. Shirin Shahangian

Academic Background

2026

Rezaei A, Aghakhani A, Bahreini F, Uversky VN. The role of tumor-infiltrating B cells in the development and pathogenesis of head and neck cancers: Implications for therapeutic approach. International Reviews of Immunology. 2026. Available at: https://www.tandfonline.com/doi/abs/10.1080/08830185.2026.2656636

Rezazadeh M, Aghakhani A, Bahreini F, Rezaei N. Extracellular RNAs in pancreatic cancer: from pathogenesis to precision medicine. Expert Opinion on Biological Therapy. 2026. Available at: https://www.tandfonline.com/doi/abs/10.1080/14712598.2026.2648644

Meybodi SM, Bahreini F, Kalies K, Reiter RJ, et al. The possible role of sirtuins and MiRNAs in gastrointestinal cancers: special focus on Sirt1. Cancer Cell International. 2026;26:99. Available at: https://link.springer.com/article/10.1186/s12935-026-04181-x

2025

Paniz MI, Tina RL, Farzaneh D, Bahreini F, Rezaei N. Bacterial Quorum Sensing: A Double-Edged Sword in Cancer Development. Advanced Biology (Weinh). 2025 Jul 21:e00023. Available at: https://pubmed.ncbi.nlm.nih.gov/40686382/

Aghakhani A, Bahreini F, Uversky VN, Rezaei N. Oral FcRn-targeted insulin: Challenges and current strategies. Journal of Drug Delivery Science and Technology. 2025. Available at: https://www.sciencedirect.com/science/article/pii/S1773224725006173

Ohmes J, Mehrpourvan A, Bahreini F, et al. Meeting Report on “The International Congress on Autoimmune Pre-disease (2024)”. JID Innovations. 2025;5(3):100342. Available at: https://www.sciencedirect.com/science/article/pii/S2667026724000900

Raudszus L, Bahreini F, Allan S, Kalies K, Caldwell C. Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity. Frontiers in Immunology. 2025;15:1494400. Available at: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1494400/full

2024

Koolivand Z, Bahreini F, Rayzan E, Rezaei N. Inducing Apoptosis in Acute Myeloid Leukemia; Mechanisms and Limitations. Heliyon. 2024;11(1). Available at: https://www.cell.com/heliyon/fulltext/S2405-8440(24)17386-0

2023

Azari M, Bahreini F, Uversky VN, Rezaei N. Current Therapeutic Approaches and Promising Perspectives of Using Bioengineered Peptides in Fighting Chemoresistance in Triple-Negative Breast Cancer. Biochemical Pharmacology. 2023;210:115459. Available at: https://www.sciencedirect.com/science/article/pii/S0006295223000503

2022

Mirtavoos-Mahyari H, Ajami S, Mehrtash A, Marashiyan SM, Bahreini F, et al. Clinical whole-exome sequencing analysis reveals a novel missense COL11A1 mutation. Clinical Case Reports. 2022;10(11):e6574. Available at: https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.6574

Ebrahimi K, Shir Ovand S, Mohammedi AA, Nabi-Afjadi M, Zalpoor H, Bahreini F. Biosynthesis of Copper Nanoparticles Using Aqueous Thymus daenensis (Celak) Flora and Investigation of Its Antifungal Activity. Journal of Medical Microbiology and Infectious Diseases. 2022;10(3):98–103. Available at: https://pdfs.semanticscholar.org/1bf9/1993ed4436b5b70d2b66d5c0603dbea8ae0b.pdf

Niebuhr M*, Bahreini F*, Fähnrich A, Bomholt C, Bieber K, Schmidt E, Ibrahim S, Hammers CM, Kalies K. Analysis of T Cell Repertoires of CD45RO CD4 T Cells in Cohorts of Patients with Bullous Pemphigoid: A Pilot Study. Frontiers in Immunology. 2022;13:1006941. (*equal contribution). Available at: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1006941/full

Taleb M, Mohammadkhani N, Bahreini F, Ovais M, Nie G. Modulation of Tumor Vasculature Network: Key Strategies. Small Structures. 2022;3(6):2100164. Available at: https://onlinelibrary.wiley.com/doi/full/10.1002/sstr.202100164

Torabi S, Bahreini F, Rezaei N. Gallium Components-Based Drug Delivery: A Potential Treatment for COVID-19. Infectious Disorders-Drug Targets. 2022;22(3):1–3. Available at: https://www.benthamdirect.com/content/journals/iddt/10.2174/1871526522666220127120617

Bahreini F, Niebuhr M, Belde J, Bieber K, Westermann J, Kalies K. Protocol to Induce Follicular T Helper Cells, Germinal Centers, and Skin Lesions in Mouse Models for Skin Blistering Diseases. Bio-protocol. 2022;12(10):e4414. Available at: https://bio-protocol.org/pdf/Bio-protocol4414.pdf

Bahreini F, Niebuhr M, Belde J, Westermann J, Kalies K. Protocol to Isolate Germinal Centers by Laser Microdissection. Bio-protocol. 2022;12(11):e4431. Available at: https://bio-protocol.org/pdf/bio-protocol4431.pdf

Bahreini F, Rayzan E, Rezaei N. MicroRNAs and Diabetes Mellitus Type 1. Current Diabetes Reviews. 2022;18(2):1–8. Available at: https://www.benthamdirect.com/content/journals/cdr/10.2174/1573399817666210215111201

2021

Bahreini F, Jabbari P, Gossing W, Aziziyan F, Frohme M, Rezaei N. The Role of Noncoding RNAs in Pituitary Adenoma. Epigenomics. 2021;13(17):1421–1437. Available at: https://www.tandfonline.com/doi/abs/10.2217/epi-2021-0165

Bahreini F, Rayzan E, Rezaei N. microRNA-Related Single-Nucleotide Polymorphisms and Breast Cancer. Journal of Cellular Physiology. 2021;236(3):1593–1605. Available at: https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.29966

2020

Torabi S, Bahreini F, Rezaei N. The Role of Angiotensin-Converting Enzyme 2 in COVID-19 Induced Lung Injury. Acta Bio Medica: Atenei Parmensis. 2020;91(4):e2020142. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7927558/

Bahreini F, Ramezani S, Shahangian SS, Salehi Z, Mashayekhi F. miR-559 Polymorphism rs58450758 is Linked to Breast Cancer. British Journal of Biomedical Science. 2020;77(1):29–34. Available at: https://www.tandfonline.com/doi/abs/10.1080/09674845.2019.1683309

  1. Bahreini F, Rezaei N. The role of microRNAs in chemoresistance. Handbook of Cancer and Immunology. DOI: 10.1007/978-3-030-80962-1_336-1 

Reviewer for

Heliyon

Cancer Genetics

Archives of Community Medicine and Public Health

SCIOLBiomedicine

Archives of Pathology and Clinical Research

PeerJ

Scientific Reports

  • International congress on autoimmune pre-disease-2024

 

Poster title: T Cell Receptor Repertoire Analysis During the Pathogenesis of the Autoimmune Skin Blistering Disease Epidermolysis Bullosa Acquisita

 

  • Conference: 50th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF)-2024

 

Poster title: T Cell Receptor Repertoire Analysis During the Pathogenesis of the Autoimmune Skin Blistering Disease Epidermolysis Bullosa Acquisita

 

  • Conference: 49th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF)- 2023

 

Poster title: Cell-derived nanoparticles regulate the pro-inflammatory cytokine secretion in the murine macrophage cell line J774A.1

 

  • 4th International & 16th Iranian Genetics Congress-2020

 

Poster title: Investigation of recombinant Lactate Dehydrogenase Expression using SUMO fusion tag

 

  • Conference: 16th National Congress of Biochemistry & 7th International Congress of Biochemistry & Molecular Biology 2020

 

 Poster title: Investigating the effect of natural deep eutectic solvents on lactate dehydrogenase activity and stability

 

  • Conference: Third International and Fifteenth Iranian Genetics Congress-2018

 

Poster title: Correlation between miR-559 gene polymorphism and susceptibility to gastric cancer

 

  • Conference: 3rd international and 11th national biotechnology congress of Islamic Republic of Iran-2019

 

Poster title: In-silico analyses to investigate miR-559 gene polymorphism and incidence of breast cancer

Skills

Next-generation sequencing
Laser microdissection
Cloning
Gene expression
Protein stability
Enzyme kinetics
ELISA
Western Blot
Chromatography
PCR
Real-time PCR
Flow Cytometry
DNA/RNA extraction
Animal Handling (Certified FELASA handler)
ZetaView
Nanosight
Cell Cultures
UV vis spectroscopy
Fluorescence spectroscopy
Recombinant Protein Production
SDS PAGE

GraphPad Prism
FlowJo
MedCalc
Microsoft Office
Excel
PowerPoint
Adobe Photoshop

*R (Intermediate): Analyzed NGS results of T cell receptor repertoire diversity using packages like ggplot2, vegan, dplyr, and immunarch for statistical analysis and visualization.
*C (Intermediate): Developed problem-solving and algorithmic skills through coursework applicable to bioinformatics tasks like data processing and simulations.
*Python (Familiar): Learned data science basics, including data manipulation (pandas), visualization (matplotlib), and introductory machine learning.

Reserch Experience

2022–Present: Research Assistant, Department of Anatomy, University of Lübeck, Germany
-Conducted research on autoimmune skin blistering diseases and mentored students

2019–2021: Research Assistant, Department of Biochemistry, Tarbiat Modares University, Iran
-Focused on hyaluronic acid extraction from rooster comb, including sample preparation and data analysis.

2018–2019: Research Assistant, Department of Biochemistry, Tarbiat Modares University, Iran,
-Worked on cloning and expression of GDNF protein, along with sample preparation and analysis.

As part of my M.Sc. thesis I investigated structural, activity, and stability alterations of lactate dehydrogenase in the presence of different additives at the Department of Biochemistry, Tarbiat Modares University, Iran

2016–2017: Junior Researcher, Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
-Worked on the role of miRNA SNPs on the incidence of breast and gastric cancer.

Affiliations

2022-present Institute of Anatomy, University of Luebeck, Luebeck, Germany

2020- present Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

2018- 2021 Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

2014-2020 Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Notable Certificates

I am thrilled to share that I have earned the Certificate of Excellence from the Researcher Academy of ELSEVIER by successfully completing the Certified Peer Reviewer Course.

This has been one of commitment and passion for enriching the quality of scientific research through peer review. I look forward to applying the insights and skills gained from this course to contribute meaningfully to the academic community.

A Good Manufacturing Practice (GMP) certificate ensures that products are consistently produced and controlled according to quality standards. It is crucial for ensuring product safety, efficacy, and regulatory compliance in industries such as pharmaceuticals and food.

Having a good scientific practice certificate ensures that researchers adhere to ethical guidelines and maintain the integrity of their work. It is essential for fostering trust, reproducibility, and accountability in scientific research.

The FELASA (Federation of European Laboratory Animal Science Associations) animal handling certificate obtained in Germany ensures that individuals are trained in the ethical and competent handling of laboratory animals. This certification is essential for maintaining high standards of animal welfare, complying with legal regulations, and promoting responsible research practices.

Languages

I am fluent in English, with a strong command of both academic and everyday language. My fluency allows me to engage confidently with global scientific literature, collaborate with international colleagues, and communicate complex ideas effectively. I continuously refine my language skills through regular practice and learning, ensuring my communication remains clear and professional.

I am currently at an A2 level in German and am actively working towards becoming proficient in the language. Through consistent study and practice, I am steadily improving my skills, aiming to reach a high level of fluency. My goal is to be able to communicate effectively in both professional and everyday contexts, and I dedicate time each day to furthering my understanding of German.

As a native speaker of Persian, I am deeply connected to the language and its rich cultural history. My fluency in Persian allows me to communicate naturally and effectively, both in professional and personal contexts, and to appreciate the nuances and expressions that come with being a native speaker.

I am familiar with the Arabic language, allowing me to understand and engage with basic conversations and texts. While I am not fully fluent, I continue to expand my knowledge and deepen my understanding of the language, particularly in a every day context.

Contact

Get in Touch

+491782943569

Luebeck, Germany

farbod_bahreini@yahoo.com

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